How Does Non-Malignant Opioid Induced Constipation (Oic) Impact Health State Utility?

• Data were pooled from 2 randomized, double-blind, placebocontrolled phase 3 studies of naloxegol conducted over 12 weeks in patients with noncancer pain and OIC (N=1352; intent-to-treat [ITT], N=1337 [KODIAC-04, NCT01309841; KODIAC-05, NCT01323790]).3 – EQ-5D4 scores were collected at baseline, week 4, and week 12 and converted into estimates of utility using the Dolan algorithm, a tariff generated based on UK general population preferences5 and according to published guidance.6 – The health utility score was set to missing if 1 or more questions were not answered on the 5 dimensions of the EQ-5D. – Based on the patient’s response for each dimension, the health utility score was calculated by subtracting the time trade-off UK weights from 1 (Table 1). Table 1. UK Time Trade-Off Weights*5,6 No Problems (Level 1) Some Problems (Level 2) Extreme Problems (Level 3) Mobility 0 0.069 0.314 Self-care 0 0.104 0.214 Pain/discomfort 0 0.123 0.386 Usual activities 0 0.036 0.094 Anxiety/depression 0 0.071 0.236